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Influence of derivatization on the chiral selectivity of cyclodextrins: Alkylated/acylated cyclodextrins and γ-/δ-lactones as an example

✍ Scribed by Hans-George Schmarr; Armin Mosandl; Astrid Kaunzinger

Publisher: John Wiley and Sons
Year: 1991
Tongue: English
Weight: 543 KB
Volume: 3
Category: Article
ISSN: 1040-7685
DOI: 10.1002/mcs.1220030503

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✦ Synopsis

Abstract

Selectively alkylated and acylated cyclodextrin derivatives are suitable stationary phases for capillary GC. To obtain a closer insight into the separation mechanism, an inverse substituted cyclodextrin derivative was synthesized and characterized, and its chiral selectivity was compared with a traditionally substituted and characterized cyclodextrin. The influence of a polar group in the cyclodextrin molecule on the enantioselectivity for γ‐/δ‐lactones is shown with a new, diacylated, cyclodextrin derivative.

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