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Preparation of β -alanine-3,3-D2 and −2,2,3,3-D4

✍ Scribed by Kazuhiko Hanai; Akio Kuwae

Publisher
John Wiley and Sons
Year
1988
Tongue
French
Weight
263 KB
Volume
25
Category
Article
ISSN
0022-2135

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✦ Synopsis

B -Alanine-3,3-d2 and -2,2,3,3-d4 were prepared via a five-step procedure from ethyl cyanoacetate. The procedure involves reduction of the starting material with lithium aluminum deuteride, followed by benzoylation of the amino alcohol obtained, oxidation of the benzoylated compound, hydrolysis of benzoyCB -alanine-3,3-d2 with hydrochloric or deuterochloric acid, and then anion exchange of the hydrochloride or the deuterochloride.

The isotopic purities of the d2 and d4 compounds were more than 98 and 97%. respectively.

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