Preparation of α-substituted α-amino acids of high enantiomeric purity
✍ Scribed by William H. Pirkle; Richard Heire; Myung Ho Hyun
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- English
- Weight
- 681 KB
- Volume
- 4
- Category
- Article
- ISSN
- 0899-0042
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📜 SIMILAR VOLUMES
## Abstract Diazotization of α‐amino acids in 48:52 (__w__/__w__) hydrogen fluoride/pyridine along with excess of potassium halide results in the corresponding α‐halocarboxylic acids in good to excellent yields __(Table 1__ and __2)__.
The synthesis of enantiomerically pure Ac-Tyr-Val-Ala-Asp(O t Bu)-H dimethyl acetal ((S)-1) is reported, a protected tetrapeptide C-terminal aldehyde belonging to a class of potent, reversible inhibitors of cysteine proteases (e.g., interleukin-1b-converting enzyme (ICE), also called caspase-1). The
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