Preparation of α-silyl- or α,α-bis(silyl)-substituted alkylcopper reagents and their synthetic use
✍ Scribed by Junichi Kondo; Atsushi Inoue; Yuki Ito; Hiroshi Shinokubo; Koichiro Oshima
- Book ID
- 108282888
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- French
- Weight
- 292 KB
- Volume
- 61
- Category
- Article
- ISSN
- 0040-4020
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📜 SIMILAR VOLUMES
Treatment of chlorobis(methyldiphenylsilyl)methyllithium with vinylic Grignard reagents and CuCN•2LiCl afforded a,a-bis(silyl)-substituted allylic copper species. The reactions of the reagents with electrophiles provided a variety of 1,1-disilylalkenes.
A new method for the stereoselective preparation of proximal b-hydroxy silyl enol ethers from a,bepoxyketones using silyllithium reagents has been developed. The reaction is believed to proceed via Brook rearrangement assisted by opening of the adjacent epoxide. A number of a,b-epoxyketones were rea
Reaction of ketene silyl acetals with allylic carbonates in the presence of palladium-phosphine catalyst in dioxane gives a-ally1 esters in high yields. When the reaction is carried out with phosphine-free palladium catalyst in nitriles,cl,fi-unsaturated esters are obtained in good yields. We have