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Preparation of tritium-labeled compounds. IV. A group of steroids by exposure to tritium gas

โœ Scribed by Richard C. Thomas; George J. Ikeda; Lester M. Reineke

Publisher
John Wiley and Sons
Year
1971
Tongue
French
Weight
419 KB
Volume
7
Category
Article
ISSN
0022-2135

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โœฆ Synopsis

Hydrocortisone, 21-desoxy-Ya~~uoro-6a-methylprednisolone, and ba-nietliylprednisolone, 21-acetate were labeled with tritium by the Wilzbach tritium-gas exposure method. The latter compourid was also tritiated by exposure to tritium gas in the presence of a platinumblack catalyst. Although extensive purgeations were required, in each rasp radiockemically pure material of suficiently high speciJic activity for its intended use was obtained. Incorporation of stably bound tritium was nine times greater by catalytic tritiation than by the conventional Wilzhach method.

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Tritium labelling of amino-acids and pep
Tritium labelling of amino-acids and peptides by the Wilzbach method. II. Racemization of amino-acids during exposure to tritium gas
โœ J. H. Parmentier ๐Ÿ“‚ Article ๐Ÿ“… 1966 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 377 KB ๐Ÿ‘ 1 views

Optically pure amino-acids were labelled with tritium by the Wilzbach method. The percentage of radioactivity found in the opposite enantiomer was determined by reverse dilution analysis. After tritiation of L-phenylalanine, D-phenylalanine, L-tyrosine, L-proline, D-proline, L-glutamic acid and L-al