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Preparation of thermosensitive polymer nanoparticles by protein-mimetic cross-linking

✍ Scribed by Sachiko Kaihara, Masatoshi Narikawa, Keiji Fujimoto

Book ID
120795358
Publisher
Springer
Year
2012
Weight
386 KB
Volume
290
Category
Article
ISSN
0340-255X

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Chemical cross-linking of gelatin is achieved using a thermosensitive reactive copolymer based on N-isopropylacrylamide (NIPAM). The copolymer bears 5 mol % acrylic acid units which form amide bonds with the amino groups of gelatin in the presence of a water-soluble carbodiimide. The cross-linking r