Preparation of tetrazoles from organic nitriles and sodium azide in micellar media

✍ Scribed by Branko S. Jursic; Blaise W. Leblanc

• Book ID: 102339351
• Publisher: Journal of Heterocyclic Chemistry
• Year: 1998
• Tongue: English
• Weight: 312 KB
• Volume: 35
• Category: Article
• ISSN: 0022-152X
• DOI: 10.1002/jhet.5570350224

✦ Synopsis

Abstract

An effective method for the preparation of 5‐substituted tetrazoles from the corresponding nitriles in micellar media is described. It was demonstrated that almost quantitative yields of tetrazoles can be obtained if the amount of water‐surfactant is optimized. The advantages of the methods presented over many others currently used are the simplicity, facility of isolation of tetrazole products and elimination of using relatively expensive solvents and reagents.