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Preparation of Substituted Piperazinones via Tandem Reductive Amination−(N,N‘-Acyl Transfer)−Cyclization

✍ Scribed by Beshore, Douglas C.; Dinsmore, Christopher J.


Book ID
115465831
Publisher
American Chemical Society
Year
2002
Tongue
English
Weight
88 KB
Volume
4
Category
Article
ISSN
1523-7060

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N-phenyl-substituted pyrrolidines, piper
✍ Richard A. Bunce; Derrick M. Herron; Jason R. Lewis; Sharadsrikar V. Kotturi 📂 Article 📅 2003 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 68 KB

## Abstract __N__‐Phenyl‐substituted pyrrolidines and piperidines have been synthesized by catalytic reduction of nitrobenzene in the presence of 4‐ and 5‐oxoaldehydes, respectively. The process involves reduction of the aromatic nitro group to give the __N__‐phenylhydroxylamine or aniline followed