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Efficient synthesis of substituted piperazinones via tandem reductive amination–cyclization

✍ Scribed by Christopher J. Dinsmore; C.Blair Zartman

Book ID
108379911
Publisher
Elsevier Science
Year
2000
Tongue
French
Weight
184 KB
Volume
41
Category
Article
ISSN
0040-4039

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Efficient synthesis of unsymmetrical 1,4
Efficient synthesis of unsymmetrical 1,4-disubstituted-2,3-diketopiperazines via tandem reductive amination–cyclization
✍ Douglas C Beshore; Christopher J Dinsmore 📂 Article 📅 2000 🏛 Elsevier Science 🌐 French ⚖ 123 KB

Herein we report the efficient syntheses of 1,4-disubstituted-2,3-diketopiperazines and 1,4,5-trisubstituted-2,3-diketopiperazines, which feature a tandem reductive amination and acylation. Aliphatic and aromatic primary amines serve as viable nucleophiles under the mild reaction conditions.