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Preparation of ring-tritiated and of aldehyde-14C-labelled 1-pyrenecarboxaldehyde

✍ Scribed by Gary H. Posner; Itzhak Barness; William H. Biggley; Howard H. Seliger; David C. Kaplan

Publisher
John Wiley and Sons
Year
1985
Tongue
French
Weight
335 KB
Volume
22
Category
Article
ISSN
0022-2135

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✦ Synopsis

A short, direct, and efficient synthesis of very high specific-activity ring-tritiated 1-pyrenecarboxaldehyde is described.

A novel aspect of this synthesis involves direct bromination of an aromatic pyrene system rrying an electronwithdrawing aldehyde group.

Synthesis of 'C-labelled l-pyrenecarboxaldehyde is also described.

Each o f these compounds was converted in one step into the correspondingly radiolabelled trans-1-( 2 ' -me thoxyvinyl ) pyrene . Key Words: vinyl)pyrene, radiolabelled PAH tritium, 14C, 1-pyrenecarboxaldehyde, I-( 2'-methoxyand I4C-2) in order to study the details of its metabolism and the intricacies of the reaction(s) of its metabolite(s) with various biomoleculcs. We describe here preparation of ring-tritiated and of aldeh~de-~~c-labelled l-pyrenecarboxaldehydes (3H-L and 14C-;) and conversion of each into the correspondingly labelled trans-MVP ( 3H-2 and l4C-?). M 0362-48O3/sS/lOlO2~Sol .oO @ 1985 by John Wiley & Sons, Ltd.

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