✦ LIBER ✦

Preparation of proline derived lithium amide bases and their use in enantioselective deprotonation of meso epoxides

✍ Scribed by Shirley K. Hendrie; John Leonard

Publisher: Elsevier Science
Year: 1987
Tongue: French
Weight: 443 KB
Volume: 43
Category: Article
ISSN: 0040-4020
DOI: 10.1016/s0040-4020(01)90297-2

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✦ Synopsis

oMo-4ozo/87 53.00+.00 Q 1987 Perpmon loumals Ltd. s. K. HENDRIB and J. b3NARD Ownlw Of t~8a~utyl~lmothy~~~,~x~clopmtme 15 to Inn~tbutyldlmothylsllox~2. cycl0pmtsn-bd 17. nBuVl lwlhrm (O.!Xml, 1 .5M, O.Ummol) wa6 adrIed to a 8ok@n of (S)-2-R Wrro-U48mg, 0.~1. h dryether(3cnr3)etOoC,under~.Aflsr30~.Me~epoxide(100mg,054mnol),hsWer(2an3)~addedandthe~n, wasa!iowedtowarmtomomt ~andsthedwlynoepoxlde~,asindcatedbync~abM8hr.~.Thes0clhbn~ then diluted with CH$b, washed with water, d&d, ev~rated and the resldur puryled hy l&h dwomatogrephy.

'I+ NMR (60 MHz) 6 0.0 (6, SJ-I), 0.8 (s. 9H), 2.6 (m, 2H), 4.9 (m, ZH), 5.8 (s, 2li);v, 3350,%%0,1060, cm-l.

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