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Preparation of Poly(D,L-lactide) and Copoly(lactide-glycolide) Microspheres of Uniform Size

✍ Scribed by K. Shiga; N. Muramatsu; T. Kondo

Book ID
118110301
Publisher
Pharmaceutical Press
Year
1996
Tongue
English
Weight
720 KB
Volume
48
Category
Article
ISSN
2042-7158

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Ketotifen-loaded microspheres prepared by spray-drying poly(D,L-lactide) and poly(D,L-lactide-co-glycolide) polymers: Characterization and in vivo evaluation
✍ Sandra Guerrero; Enriqueta MuΓ±Γ­z; CΓ©sar TeijΓ³n; Rosa Olmo; JosΓ© M. TeijΓ³n; M. Do πŸ“‚ Article πŸ“… 2008 πŸ› John Wiley and Sons 🌐 English βš– 629 KB

Ketotifen (KT) was encapsulated into poly(D,L-lactide) (PLA) and poly(D,Llactide-co-glycolide) (PLGA 50/50) by spray-drying to investigate the use of biodegradable drug-loaded microspheres as delivery systems in the intraperitoneal cavity. Ketotifen stability was evaluated by HPLC, and degradation w