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Preparation of optically pure chiral amines by lipase-catalyzed enantioselective hydrolysis ofN-acyl-amines

✍ Scribed by Hauke Smidt; Andreas Fischer; Peter Fischer; Rolf D. Schmid

Publisher: Springer-Verlag
Year: 1996
Tongue: English
Weight: 275 KB
Volume: 10
Category: Article
ISSN: 0951-208X
DOI: 10.1007/bf00173249

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✦ Synopsis

A new and effective method using lipase from Candida antarctica (native or Novozym SP-435) for the preparation of enantiopure primary R-amines is reported. Hydrolysis of rat-N-acetyl-amines resulted in high conversion > 40% (168 hrs) and > 48 % (> 240 hrs) and enantiomeric excesses (> 99 %ee) for both the product and the remaining substrate.

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