Candida rugosa lipase-catalyzed enantioselective hydrolysis in organic solvents. Convenient preparation of optically pure 2-hydroxy-2-arylethanephosphonates

✍ Scribed by Yonghui Zhang; Zuyi Li; Chengye Yuan

• Publisher: Elsevier Science
• Year: 2002
• Tongue: French
• Weight: 65 KB
• Volume: 43
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(02)00443-4

✦ Synopsis

A convenient enzymatic method is presented for the preparation of optically pure 2-hydroxy-2-arylethanephosphonates. It is proved that 2-butyryloxy-2-arylethanephosphonates can be enantioselectively hydrolyzed in diisopropyl ether equilibrated with water to give both isomers in high yield and excellent enantiomeric excess.