Preparation of nitriles from primary amides under Swern oxidation conditions

✍ Scribed by Noriyuki Nakajima; Makoto Ubukata

• Publisher: Elsevier Science
• Year: 1997
• Tongue: French
• Weight: 218 KB
• Volume: 38
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(97)00316-x

✦ Synopsis

In order to establish a mild conversion method of primary amides to nitriles, various types of carboxc~nides were treated under Sw ern oxidation conditions, ( COCI)2-DMSO and Et3N, as a dehydrating agent to obtain desired nitriles in 75-96% yields.