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Preparation of N′4-[11C]methyl-ciprofloxacin for positron emission tomography studies

✍ Scribed by Patrick Goethals; Anneke Volkaert

Publisher
John Wiley and Sons
Year
2002
Tongue
French
Weight
76 KB
Volume
45
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

The synthesis of N′~4~‐[^11^C]methyl‐ciprofloxacin for pharmacological studies using positron emission tomography is described. The starting material was treated with [^11^C]methyl iodide at 120°C in DMF for 5 min. After HPLC separation on a C~18~‐column with water/ethanol as mobile phase, the [^11^C]methyl labelled compound was produced with a radiochemical yield of at least 25% (end of synthesis from [^11^C]CO~2~). Activities from 1.48 to 2.22 GBq (40 to 60 mCi) were obtained 1 h after the irradiation, ready for intravenous injection. The carrier ranged between 0.05 and 0.08 μmol (0.010–0.016 μmol/ml). Copyright © 2002 John Wiley & Sons, Ltd.

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