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Preparation of N-benzylsulfonamido-1,2-dihydroisoquinolines and their reaction with Raney nickel. A mild, new synthesis of isoquinolines

✍ Scribed by Enrique L. Larghi; Teodoro S. Kaufman


Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
234 KB
Volume
38
Category
Article
ISSN
0040-4039

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✦ Synopsis


N-benzylsulfonamido-12-dihydroisoquinolines react with Raney nickel to provide isoquinolines in excellent yields and under mild, neutral conditions.


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Synthesis of 1,2-Dihydroisoquinolines by the Reaction of Isoquinoline with Allyltributyltin or Silyl Enol Ethers in the Presence of N-Acylating Agents. -Isoquinolines (I) react with allyltributyltin or silyl enol ethers (V) in the presence of acylating agents (III) to give the 1,2-adducts (IV) and