Preparation of N-[11C]methyl-2,5-dimethoxy-4-bromo-amphetamine
✍ Scribed by M. Solbach; D. Gündisch; A. Blocher; K. A. Kovar; H. J. Machulla
- Book ID
- 105442302
- Publisher
- Springer
- Year
- 1997
- Tongue
- English
- Weight
- 156 KB
- Volume
- 221
- Category
- Article
- ISSN
- 1588-2780
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Treatment of methyl 2,3-pentadienoate, 3, with bromine in carbon tetrachloride affords a complex mixture. whose main products are methyl (g)-and fZ)-3,4-dibromo-2-pentenoate, 9 and 10, and I-bromo-5methyl-5E-furan-2zone, 4. The mechanism of formation of these and other minor compounds is discussed.
## Abstract 1,2‐Dimethoxy‐4‐(bis‐diethylaminoethyl‐[^14^C]‐amino)‐5‐bromobenzene (III) was synthesized for __in vivo__ pharmacokinetic and pharmacodynamic evaluation. The synthesis of (III) was easily obtained by the direct alkylation of 1,2‐dimethoxy‐5‐bromo‐aniline with beta‐diethylaminoethyl chl