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Preparation of Monodispersed Solid Lipid Microspheres Using a Microchannel Emulsification Technique

✍ Scribed by Shinji Sugiura; Mitsutoshi Nakajima; Jihong Tong; Hiroshi Nabetani; Minoru Seki

Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
455 KB
Volume
227
Category
Article
ISSN
0021-9797

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✦ Synopsis

Monodispersed solid lipid microspheres consisting of high melting point edible oil were prepared as a novel sophisticated material. To prepare the monodispersed solid lipid microspheres a temperature-controlled microchannel (MC) emulsification process was devised. The prepared microspheres had diameters of approximately 20 Β΅m or more and the standard deviation of the diameters was less than 1 Β΅m. The effects of different surfactants, the pressure and the shape of the MC on the MC emulsification, and the diameter of the prepared droplet were studied. The experimental results are discussed using the new mechanism of droplets formation which is caused by the interfacial tension.

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