A T-2 toxin specific monoclonal antibody, IgGl K, with a low level of ELISA cross-reactivity to Acetyl T-2, HT-2, and is0 T-2 toxins has been produced. The ability of this monoclonal antibocly to neutralize the cytotoxicity of T-2 toxin in PHA stimulated cultures of human lymphocytes was determined
✦ LIBER ✦
Preparation of monoclonal antibodies to staphylococcal α-toxin by in vitro immunization
✍ Scribed by N. N. Belyaev; G. K. Zakir'yanova; G. O. Kostin; R. T. Tleulieva; A. O. Agashkin; D. G. Navasardyants; Yu. V. Ezepchuk; A. B. Beklemishev
- Publisher
- Springer US
- Year
- 1991
- Tongue
- English
- Weight
- 600 KB
- Volume
- 112
- Category
- Article
- ISSN
- 0007-4888
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We describe a novel version of antibody-directed enzyme prodrug therapy (ADEPT), with the use of amygdalin as prodrug. Amygdalin is a naturally occurring cyanogenic glycoside, which can be cleaved by sweet almond -glucosidase to yield free cyanide. If amygdalin could be activated specifically at th