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Preparation of Ketones from α,α-Disubstituted Acetoacetic Esters

✍ Scribed by Renfrow, W. B.; Walker, G. B.


Book ID
127330869
Publisher
American Chemical Society
Year
1948
Tongue
English
Weight
284 KB
Volume
70
Category
Article
ISSN
0002-7863

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Solid phase synthesis of α-acylamino-α,α
✍ Colin M. Tice; Enrique L. Michelotti; Ernesto G. Mata; Ernesto Nicolàs; Javier G 📂 Article 📅 2002 🏛 Elsevier Science 🌐 French ⚖ 150 KB

a-Acylamino-a,a-disubstituted ketones are of interest as ecdysone agonists. Solid phase synthesis of prototypical a-acylamino-a,a-disubstituted ketones on two different solid supports is described. In both cases the ketone was formed by reaction of a Grignard reagent with an N-acyl-a,a-disubstituted