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Preparation of gelatin hydrogels incorporating small interfering RNA for the controlled release

✍ Scribed by Saito, Takashi; Tabata, Yasuhiko

Book ID
124053854
Publisher
Informa plc
Year
2012
Tongue
English
Weight
867 KB
Volume
20
Category
Article
ISSN
1061-186X

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In this paper, we demonstrate a simple and practical method to prepare chemically crosslinked gelatinbased hydrogels using b-cyclodextrin (b-CD) that plays a dual role as a crosslinker as well as a host molecule for enhanced binding of anticancer drug methotrexate (MTX), to achieve high drug loading