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Preparation of formacetal-linked purine-purine dinucleotide analogs

✍ Scribed by Gong-Xin He; Norbert Bischofberger

Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
213 KB
Volume
38
Category
Article
ISSN
0040-4039

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✦ Synopsis

Protected formacetal-linked purine-purine dinucleotide analogs, including dG-f-dG, dG-f-dA, dA-f-dG, and dA-f-dA, were synthesized for the first time in 40 -60% yields by condensation of the 5'-OH group with the 3'-OCH2SCH3 group of the two corresponding deoxynucleoside units using N-iodosuccinimide in the presence of 2.5 eq of trifluoromethanesulfonic acid at -30°C.

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