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Synthesis of novel carbazoyl linked pyrimidine-pyrimidine and pyrimidine-purine dinucleotide analogues

✍ Scribed by Julia Magdalena; Susana Fernández; Miguel Ferrero; Vicente Gotor

Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
224 KB
Volume
40
Category
Article
ISSN
0040-4039

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✦ Synopsis

The synthesis of two backbone modified dinucleotide analogues is described in which the natural phosphodiester linkage is replaced by a 3'-5" c~xbazoyl linkage. In both cases the bridge was formed through a coupling reaction between an appropriate 3'-carbazoyl nucleoside analogue and an aldehyde nucleoside derivative. It is noteworthy that s~,ting nucleosides 4 could be common materials to obtain the 3'-carbazoyi nucleoside derivatives 2, by means of a simple, previouslydescribed chemoenzymatic procedure, and the aldehyde nucleoside 3, by an oxidation reaction.

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