Preparation of Ethyl ( R )-3-hydroxy-4-chlorobutyrate by Selective Reduction of ( R )-4-(Trichloromethyl)-oxetan-2-one: Key Intermediate to ( R )-Carnitine and ( R )-4-Amino-3-hydroxybutyric Acid
β Scribed by Song, Choong Eui; Lee, Jae Kyun; Kim, In O; Choi, Jung Hoon
- Book ID
- 127274920
- Publisher
- Taylor and Francis Group
- Year
- 1997
- Tongue
- English
- Weight
- 205 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0039-7911
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π SIMILAR VOLUMES
## Microbial enantioselective hydrolysis of diethyl-3-hydroxyglutarate afforded (S)-ethyl hydrogen-3_hydroxyglutarate, which was transformed into (R)-4-amino-3-hydroxybutyric acid and L-carnitine, via a Curtius and Hunsdiecker rearrangement, respectively.
The preparative separation of the enantiomers of the title compound, a versatile chiral building block for the synthesis of unnatural amino acid esters, by high performance liquid chromatography on a chiral stationary phase (CSP), is reported for the first time. The CSP consists of amylose-(3,5-dime