Preparation of deuterated arachidonic acid
β Scribed by D.F. Taber; M.A. Phillips; W.C. Hubbard
- Book ID
- 119049157
- Publisher
- Elsevier Science
- Year
- 1981
- Tongue
- English
- Weight
- 260 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0090-6980
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π SIMILAR VOLUMES
mandelic a c i d (commonly r e f e r r e d t o as v a n i l l y l m a n d e l i c a c i d (VMA)) l a b e l l e d w i t h deuterium i n t h e methoxy group has been prepared b o t h e n z y m a t i c a l l y , from S-adenosyl-L-methionine-methyl-d3 and dihydroxymandelic a c i d u s i n g c a t e c h
The synthesis of arachidonic acid derivatives containing site-specifically incorporated deuterium atoms and also a remote tritium label are described. Deuterium incorporation at the C11 and/or C15 position was achieved using Wittig chemistry, while the radiolabel was introduced at a remote position
## Abstract Two new photochemical methods are described to prepare Dβ1βbenzaldehydes of high isotopic purity in good yield.