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Preparation of crystallinep-nitrobenzyl 2-hydroxymethyl carbapenem as a key intermediate for the anti-MRS carbapenem L-786,392

✍ Scribed by Nobuyoshi Yasuda; Chunhua Yang; Kenneth M. Wells; Mark S. Jensen; David L. Hughes

Book ID: 104260421
Publisher: Elsevier Science
Year: 1999
Tongue: French
Weight: 274 KB
Volume: 40
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(98)02393-4

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✦ Synopsis

Crystalline p-nitrobenzyl esters of 2-hydroxymethyl carbapenem derivatives were prepared in one pot from the corresponding diazo compounds and Bu3SnCH2OH. The TES protected 2-hydroxymethyl carbapenem was successfully converted to an anti-MRS carbapenem L-786,392.

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