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Preparation of chiral propargylic alcohols from α,β-unsaturated esters

✍ Scribed by Jiong Chun; Hoe-Sup Byun; Robert Bittman

Publisher
Elsevier Science
Year
2002
Tongue
French
Weight
143 KB
Volume
43
Category
Article
ISSN
0040-4039

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✦ Synopsis

A series of chiral propargylic alcohols with high enantiomeric excess was prepared by asymmetric dihydroxylation of a,b-unsaturated esters, conversion of the diols to 4-(chloromethyl)-1,3-dioxolane intermediates, and base-induced elimination.

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