Preparation of activated benzofurans and their reactions with aldehydes

✍ Scribed by David St.C. Black; Donald C. Craig; Naresh Kumar; Robert Rezie

• Publisher: Elsevier Science
• Year: 1999
• Tongue: French
• Weight: 763 KB
• Volume: 55
• Category: Article
• ISSN: 0040-4020
• DOI: 10.1016/s0040-4020(99)00152-0

✦ Synopsis

Reactions of 3-substituted 4,6-dimethoxybenzofurans with formaldehyde and aryl aldeydes in the presence of acetic acid and phosphoryl chloride respectively give new macrocyclic calix[3]benzofurans, predominantly with an unsymmetrical linkage pattern. Incorporation of a t-butyl substituent at the 3-position, however, leads to the formation of only a trimer with a symmetrical linkage pattern.