Preparation of a fluorous protecting group and its application to the chemoenzymatic synthesis of sialidase inhibitor
โ Scribed by Ikeda, Kiyoshi; Mori, Hitomi; Sato, Masayuki
- Book ID
- 120474746
- Publisher
- Royal Society of Chemistry
- Year
- 2006
- Tongue
- English
- Weight
- 301 KB
- Volume
- 29
- Category
- Article
- ISSN
- 1359-7345
- DOI
- 10.1039/b605519b
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
A recyclable fluorous labeled THP protecting group has been developed that allows for simple purification of small molecules by liquid-liquid extraction with FC-72/MeCN, and of larger or more polar molecules by solid phase extraction with fluorous reverse phase silica gel. In addition, we report a n
Synthesis and Applications of a Fluorous THP Protective Group. -A variety of alcohols (IX) can be protected with a fluorous labeled THP protecting group using the Cp 2 ZrCl 2 -AgClO 4 reagent system to activate the sulfoxide (VII). The protected alcohols (X) can be easily purified by liquid-liquid
A readily recyclable, fluorous alkoxy ethyl ether protecting group has been developed that allows for simple purification of small to medium-sized organic molecules by liquid-liquid extraction with FC-72/organic/aqueous solvents. The precursor vinyl ether 3 can be prepared in large quantity in a str