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Preparation of 5-Substituted 1H-Tetrazoles from Nitriles in Water†

✍ Scribed by Demko, Zachary P.; Sharpless, K. Barry


Book ID
115467181
Publisher
American Chemical Society
Year
2001
Tongue
English
Weight
88 KB
Volume
66
Category
Article
ISSN
0022-3263

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Preparation of 5-Substituted 1H-Tetrazol
✍ Demko, Zachary P.; Sharpless, K. Barry 📂 Article 📅 2001 🏛 American Chemical Society 🌐 English ⚖ 88 KB

The addition of sodium azide to nitriles to give 1H-tetrazoles is shown to proceed readily in water with zinc salts as catalysts. The scope of the reaction is quite broad; a variety of aromatic nitriles, activated and unactivated alkyl nitriles, substituted vinyl nitriles, thiocyanates, and cyanamid