Preparation of 5-Substituted 1H-Tetrazol
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Demko, Zachary P.; Sharpless, K. Barry
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Article
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2001
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American Chemical Society
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English
⚖ 88 KB
The addition of sodium azide to nitriles to give 1H-tetrazoles is shown to proceed readily in water with zinc salts as catalysts. The scope of the reaction is quite broad; a variety of aromatic nitriles, activated and unactivated alkyl nitriles, substituted vinyl nitriles, thiocyanates, and cyanamid