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Isolation and Crystallographic Characterization of a Solid Precipitate/Intermediate in the Preparation of 5-Substituted 1 H -Tetrazoles from Nitrile in Water

✍ Scribed by Wang, Li-Zhong; Qu, Zhi-Rong; Zhao, Hong; Wang, Xi-Sen; Xiong, Ren-Gen; Xue, Zi-Ling


Book ID
120416648
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
221 KB
Volume
42
Category
Article
ISSN
0020-1669

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Preparation of 5-Substituted 1H-Tetrazol
✍ Demko, Zachary P.; Sharpless, K. Barry πŸ“‚ Article πŸ“… 2001 πŸ› American Chemical Society 🌐 English βš– 88 KB

The addition of sodium azide to nitriles to give 1H-tetrazoles is shown to proceed readily in water with zinc salts as catalysts. The scope of the reaction is quite broad; a variety of aromatic nitriles, activated and unactivated alkyl nitriles, substituted vinyl nitriles, thiocyanates, and cyanamid