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Preparation of 5-bromo-6-phenylimidazo[2,1-b][1,3,4]thiadiazol-2-ylamines

✍ Scribed by Saifidin Safarov; Rahmonov Rahmon; Muhamacho Amadovich Kukaniev; Dieter Schollmeyer; Elena Karpuk; Herbert Meier

Publisher
Journal of Heterocyclic Chemistry
Year
2008
Tongue
English
Weight
300 KB
Volume
45
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

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The reaction of primary or secondary amines with 2,5‐dibromo‐6‐phenylimidazo[2,1‐b][1,3,4]‐thiadiazole (5) leads to a chemoselective replacement of the 2‐Br substituent. The process represents a convenient route to the corresponding 2‐ylamines 7a‐d. Hydrazine reacts in an analogous fashion (5 → 7e). The structure determinations are based on an X‐ray crystal structure analysis and on one‐ and two‐dimensional NMR measurements.

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Bicyclic thiadiazoles I: 2-(2-thienyl)-5-phenylthiazolo[2,3-b]-1,3,4-thiadiazole
✍ Man M. Kochhar; Mohammad Salahi-Asbahi; Byron B. Williams 📂 Article 📅 1973 🏛 John Wiley and Sons 🌐 English ⚖ 216 KB

hydrates could be air milled, the author proceeded to pnpare suspensions with air-milled hydrate to see if crystal growth still oe curted. Work was done with I-hydrate, because at that time development work on 11 had been discontinued. A 2.5% suspension of air-milled I-hydrate was made (Table ) and