Preparation of 5-(2-Methoxy-4-nitrophenyl)oxazole: A Key Intermediate for the Construction of VX-497
β Scribed by Herr, R. Jason; Fairfax, David J.; Meckler, Harold; Wilson, Jeffrey D.
- Book ID
- 120514568
- Publisher
- American Chemical Society
- Year
- 2002
- Tongue
- English
- Weight
- 67 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1083-6160
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π SIMILAR VOLUMES
The enantioselective hydrogenation of (E)-2-(4-methoxy-3-(3-methoxypropoxy)-benzylidene)-3-methylbutanoic acid (1) to (R)-2-(4-methoxy-3-(3-methoxypropoxy)-benzyl)-3-methylbutanoic acid (2)-a key intermediate in the synthesis of the pharmacologically important renin inhibitor Aliskiren-is described.
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