## Abstract We report an efficient entry into substituted 3β(Οβaminoalkyl)βbenzo[__b__]thiophenes that allows rapid generation of structural diversity. Alkylation of Ξ±,Οβdihaloketones with thiophenols followed by acidβcatalysed cyclisation led to an efficient synthesis of 3β(Οβaminoalkyl)benzo[__b_
Preparation of 3-Aminoalkylbenzo[b]thiophenes.
β Scribed by Frank Burkamp; Stephen R. Fletcher
- Publisher
- John Wiley and Sons
- Year
- 2003
- Weight
- 177 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0931-7597
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Synthesis of Polyfunctionalized Thiophenes and Enediynes via Ring-Opening Reactions of 3-Lithiated Thieno[2,3-b](and [3,2b])thiophenes , 3,4-Dilithiated Thieno[2,3-b]thiophenes and3,6-Dilithiated Thieno[3,2-b]thiophenes. -Solutions of title lithiated thienothiophenes are obtained from the correspond
## Abstract An efficient one pot access to variously substituted thieno[2,3β__b__]thiophene is described. The title compounds were obtained from 1,3βdicarbonyl or equivalent compounds, carbon disulfide and halomethyl derivatives in good to high yields and fully characterized.
Rust) 160 (calc. 165.2); Amax= 247mp (log⬠= 3.89);222mp (log E = 4.38) [3]) is obtained in 79 % yield.