A synthesis of 3-cyano-4-methyl-5 ( 14 C)-methyl-2-(5-14C)pyrrolyloxamic acid is described. The compound, having specific activity of 66.7 pCi/mmole, was obtained in 19.68% overall yield from uniformly labelled 14C-l-alanine. 14 14 Key Words: 3-Cyano-4-methyl-5( C)-methyl-2-(5-C)pyrrolyloxamic acid,
Preparation of 3, 5-dimethylpyrazole-3, 5-14C and its hypoglycemic metabolite, 5-methylpyrazole-3-carboxylic acid-5-14C
โ Scribed by Richard C. Thomas
- Publisher
- John Wiley and Sons
- Year
- 1978
- Tongue
- French
- Weight
- 272 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0022-2135
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โฆ Synopsis
3,5-Dimethylpyrazole-3,5-"T and i t s h oglycemic metabo-1 i t e , 5-methyl pyrazole-3-carboxyl i c acid-5-%.
were each prepared by separate two-step reaction sequences from acetone-2-4C i n 38% and 46% yields, respectively.
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## Abstract The inventory of labeled compounds and methods for their preparation are constantly growing, but still more building blocks of biologically relevant compounds need to be developed. Furans are frequently encountered in bioactive molecules, and a good synthesis of labeled furan is found i