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Preparation of 18F-labeled 6- and 2-fluoro-9-benzylpurine as a potential brain-scanning agent

โœ Scribed by Toshiaki Irie; Kiyoshi Fukushi; Osame Inoue; Toshiro Yamasaki; Tatsuo Ido; Tadashi Nozaki


Book ID
107769125
Publisher
Elsevier Science
Year
1982
Weight
269 KB
Volume
33
Category
Article
ISSN
0020-708X

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A new PET tracer for COX-2 imaging, the 6-ethoxy-3-(4-methanesulfonylphenyl)-4-(4-[ 18 F]fluorophenyl)pyran-2-one ([ 18 F]EFMP), was synthesized. For F-18 radiolabeling, a trimethylammonium precursor and a brominated precursor were synthesized from 1,1,2,3-tetrachlorocycloprop-2-ene in 6 steps. The