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Preparation of 1,2,4-trisubstituted imidazoles by ammonolysis of N-(2-oxoalkyl)oxazolinium salts

✍ Scribed by Matthew P John; Stephen A Hermitage; James R Titchmarsh


Book ID
104251896
Publisher
Elsevier Science
Year
2002
Tongue
French
Weight
140 KB
Volume
43
Category
Article
ISSN
0040-4039

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✦ Synopsis


A variety of aryl and alkyl substituted imidazoles have been prepared by the ring opening of N-(2-oxoalkyl)oxazolinium salts with ammonia.


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Parallel synthesis of 1,2,4-trisubstitut
✍ James M. Cobb; Neil Grimster; Nawaz Khan; Justine Y.Q. Lai; Helen J. Payne (nΓ©e πŸ“‚ Article πŸ“… 2002 πŸ› Elsevier Science 🌐 French βš– 154 KB

The synthesis of 1,2,4-trisubstituted imidazoles was demonstrated via the solid phase synthesis of N-alkyl-N-(bketo)amides using a carbazate linker. The approach enabled the assembly of a diverse number of N-alkyl-N-(b-keto)amide intermediates in good yield and purity. Subsequent cyclisation in solu