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Preparation, in vitro and in vivo evaluation of 99mTc-Annexin B1: A novel radioligand for apoptosis imaging

✍ Scribed by Quan-yong Luo; Zhi-yong Zhang; Fang Wang; Han-kui Lu; Yu-zhi Guo; Rui-sen Zhu


Book ID
116291116
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
204 KB
Volume
335
Category
Article
ISSN
0006-291X

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## Abstract Lactadherin is an opsonin, which binds with high affinity to phosphatidylserine exposed on the surface of apoptotic cells via its C1C2 domains. Phagocytosis of the apoptotic cells is then facilitated by an Arg‐Gly‐Asp (RGD)‐ mediated binding to macrophages surface integrins. The present