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Preparation and bioevaluation of99mTc-HYNIC-annexin B1 as a novel radioligand for apoptosis imaging

✍ Scribed by Quan-Yong Luo; Fang Wang; Zhi-Yong Zhang; Yi Zhang; Han-Kui Lu; Shu-Han Sun; Rui-Sen Zhu

Book ID
106349663
Publisher
Springer
Year
2008
Tongue
English
Weight
354 KB
Volume
13
Category
Article
ISSN
1360-8185

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## Abstract Lactadherin is an opsonin, which binds with high affinity to phosphatidylserine exposed on the surface of apoptotic cells via its C1C2 domains. Phagocytosis of the apoptotic cells is then facilitated by an Arg‐Gly‐Asp (RGD)‐ mediated binding to macrophages surface integrins. The present