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Preparation, hydrolysis, and oral absorption of .alpha.-carboxy esters of carbenicillin

โœ Scribed by Clayton, J. Peter; Cole, Martin; Elson, Stephen W.; Hardy, Kenneth D.; Mizen, Linda W.; Sutherland, Robert

Book ID
119997281
Publisher
American Chemical Society
Year
1975
Tongue
English
Weight
700 KB
Volume
18
Category
Article
ISSN
0022-2623

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The intestinal absorption of a-esters of carbenicillin disodium, carbenicillin phenyl sodium, and carbenicillin indanyl sodium was investigated using the in situ rat intestinal recirculating method. In the in situ intestinal lumen a t pH 7, two prodrugs were rapidly converted to poorly absorbable ca