✦ LIBER ✦

Preparation, characterization and release profiles of pH-sensitive chitosan beads

✍ Scribed by Gupta, K?C; Ravi Kumar, M?N?V

Publisher: John Wiley and Sons
Year: 2000
Tongue: English
Weight: 356 KB
Volume: 49
Category: Article
ISSN: 0959-8103
DOI: 10.1002/(sici)1097-0126(200002)49:2<141::aid-pi303>3.0.co;2-0

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✦ Synopsis

Spherical crosslinked beads using chitosan, glycine and glutaraldehyde were prepared for controlled release formulations. Structural investigation of the beads was made with IR analysis. Morphological study of the beads was carried out by scanning electron microscopy. The swelling behaviour of the beads was monitored as a function of time in solutions of different pH. The release experiments were performed using thiamine hydrochloride (Thi-HCl) as a model drug. These preliminary results suggest the possibility of modifying the formulations to obtain the desired controlled release of drug in an oral sustained delivery system.

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