𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Preparation, characterization and biological evaluation of 99mTc(CO)3-labelled cyclic polyamines

✍ Scribed by H. P. Vanbilloen; K. Eraets; N. Evens; C. Terwinghe; D. Rattat; G. Bormans; L. Mortelmans; A. M. Verbruggen

Publisher
John Wiley and Sons
Year
2005
Tongue
French
Weight
114 KB
Volume
48
Category
Article
ISSN
0022-2135

No coin nor oath required. For personal study only.

✦ Synopsis

Three cyclic polyamines, namely 1,4,7-triazacyclononane, 1,4,7,10-tetraazacyclododecane (cyclen) and 1,4,8,11-tetraazacyclotetradecane (cyclam), were evaluated as potential ligands for complexation of a technetium(I) tricarbonyl core. They can be used as bifunctional chelating agents for labelling bioactive compounds. Each of the three ligands forms a positively charged technetium tricarbonyl complex in high yield but heating is required to promote complex formation. The charge of the 99m Tc(I)tricarbonyl labelled derivatives was confirmed using electrophoresis, and radio-LC-MS supports their proposed chemical identity. After i.v. injection in mice, the compounds were rapidly cleared from the blood by the hepatobiliary or urinary pathway depending on their lipophilicity.

📜 SIMILAR VOLUMES

Preparation and biological evaluation of
Preparation and biological evaluation of 99mTc-stannous fluoride colloid-labelled-leucocytes in rats 99mTc-stannous fluoride-labelled-leucocytes in rats
✍ C. Tsopelas; E. Smith; P.A. Drew; F.D.L. Bartholomeusz 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 French ⚖ 122 KB

## Abstract High splenic activity is always visible in ^99m^Tc‐stannous fluoride (SnF~2~)‐labelled‐leucocytes scans. In an attempt to reduce this activity, this study investigated the effect of pre‐injected SnF~2~ colloid on the distribution of ^99m^Tc‐SnF~2~ colloid, ^99m^Tc‐SnF~2~‐labelled‐leucoc

Synthesis and biological evaluation of 9
Synthesis and biological evaluation of 99mTc(CO)3(IDA-CPT) for tumor imaging
✍ Jianjun Wang; Tingting Niu; Jing Yang; Cunmin Tan; Xiaobei Zheng; Wangsuo Wu; Fe 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 French ⚖ 89 KB

## Abstract This work reports the synthesis, radiolabeling, and preliminary biodistribution results in tumor‐bearing mice of ^99m^Tc(CO)~3~(IDA‐CPT). The novel camptothecin (CPT) derivate was successfully synthesized by conjugation of iminodiacetic acid (IDA) to camptothecin via a short carbonyl‐me

Synthesis, characterization and biologic
Synthesis, characterization and biological activity of 99mTc-labeled piperidine analogues targeting sigma receptors
✍ Drishty Satpati; Ketaki Bapat; Haladhar Dev Sarma; Meera Venkatesh; Sharmila Ban 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 French ⚖ 310 KB

## Abstract Sigma receptors are expressed in high density in various types of cancer cells including brain tumours and are also involved in various diseases of central nervous system. This makes ligands that bind to these receptors, attractive molecular vectors for targeting radiation to the specif

Synthesis and Preliminary Biological Eva
Synthesis and Preliminary Biological Evaluation of the 99mTc Labeled Nitrobenzoimidazole and Nitrotriazole as Tumor Hypoxia Markers.
✍ Yu Zhang; Taiwei Chu; Xuguang Gao; Xinqi Liu; Zhi Yang; Zhenquan Guo; Xiangyun W 📂 Article 📅 2006 🏛 John Wiley and Sons ⚖ 8 KB

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.

Comparing hypoxia-targeting potential of
Comparing hypoxia-targeting potential of 99mTc(CO)3-labeled 2-nitro and 4-nitroimidazole
✍ Madhava B Mallia; Suresh Subramanian; Anupam Mathur; H.D. Sarma; Meera Venkatesh 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 French ⚖ 157 KB

Non-invasive determination of hypoxia is an important problem in clinical nuclear medicine. Although 18 F-fluoromisonidazole is used clinically for hypoxia determination, the short half-life (t 1/2 = 109.77 min), high cost and less availability of cyclotrone-produced 18 F make 99m Tc (t 1/2 = 6 h)-b