Preparation, Characterization and Biodegradation Characteristics of Poly(adipic anhydride-co-D,L -lactide)

✍ Scribed by Zhu, K. J.; Lei, Yuan

• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 456 KB
• Volume: 43
• Category: Article
• ISSN: 0959-8103
• DOI: 10.1002/(sici)1097-0126(199707)43:3<210::aid-pi763>3.0.co;2-#

✦ Synopsis

Poly(adipic anhydride-co-D,L-lactide) (P(AA-LA)) has been synthesized by ring-opening polymerization of adipic anhydride (AA) and D,L-lactide (LA) using stannous octoate as catalyst in bulk and in solution. The copolymers were characterized by IR, nuclear magnetic resonance, gel permeation chromatography and di †erential scanning calorimetry. The physical properties can be tailored by varying the copolymer compositions, and showed low glass transition temperature, melting temperature and good solubility in common solvents. In vitro tests showed that after rapid weight loss in the Ðrst day, a constant degradation rate was observed. The release proÐles of model drugs, bovine serum albumin and norethindrone over 16 days followed closely that of the degradation of copolymers containing higher amounts of AA (AA [ 64 mol%), suggesting that the release mechanism was controlled predominantly by surface erosion. However, a large deviation from the close correlation of polymer degradation and drug release was observed for copolymers containing lower amounts of AA (\30 mol%). These materials may be useful in protein delivery systems.