Preparation, characterization and degradation characteristics of polyanhydrides containing poly(ethylene glycol)

✍ Scribed by Jiang, H L; Zhu, K J

• Publisher: John Wiley and Sons
• Year: 1999
• Tongue: English
• Weight: 177 KB
• Volume: 48
• Category: Article
• ISSN: 0959-8103
• DOI: 10.1002/(sici)1097-0126(199901)48:1<47::aid-pi107>3.0.co;2-x

✦ Synopsis

Poly(ethylene glycol) (PEG) segments were introduced into a polyanhydride main chain by copolymerization of terminal-carboxylated poly(ethylene glycol) with diacidic monomers (sebacic acid and trimellitylimidoglycine). IR and 1H NMR spectroscopy conürmed the copolymer structures. DSC analysis showed that these polyanhydrides have low and low crystallinity. In vitro degradation T g tests indicated that introducing PEG segments accelerated the degradation rate of these polymers and the degradation duration could be manipulated from 3 days to 3 weeks. The pH of the environment caused by the polymer degradation was lower than 5.0 ; therefore, the polyanhydrides could be used as components of a newly designed pulsed-release device for peptide and protein delivery.