Preparation of (6R)-tetrahydrofolic acid
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Judith K. Sato; Edward M. Newman; Richard G. Moran
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Article
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1986
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Elsevier Science
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English
β 677 KB
Commercially available 5-formyltetrahydrofolate (5-CHO-H4PteGlu) is chemically prepared in a reaction that introduces an asymmetric center at the 6 carbon, and hence is the mixture of diastereomers differing in chirality about this position. (6R)-5-CHO-H4PteGlu, the diastereomer that is not normally