Preparation and stability of a radioiodinated pentamidine isethionate analog

✍ Scribed by Philip J. Blower; Claire M. Smith; Raymond J. Smith; Gareth E. Moores; Michael J. O'Doherty

• Book ID: 103922916
• Publisher: Elsevier Science
• Year: 1992
• Weight: 512 KB
• Volume: 43
• Category: Article
• ISSN: 0883-2889
• DOI: 10.1016/0883-2889(92)90193-i

✦ Synopsis

Iodopentamidine isethionate was heated for 70 min with [I-123]- or [I-125]-sodium iodide and ammonium sulphate in the absence of solvent at 140 degrees C. The product, [I-123]- or [I-125]-iodopentamidine isethionate, was purified by ion exchange chromatography. It was stable at room temperature in aqueous solution over several days, in human blood in vitro for at least 24 h (showing no binding to either cells or proteins), in urine over at least 15 h, and during nebulization in both ultrasonic and jet nebulizers.