Preparation and retention behaviour of chemically bonded methylated-cyclodextrin stationary phases for liquid chromatography

✍ Scribed by Minoru Tanaka; Yoshihiro Kawaguchi; Takashi Niinae; Toshiyuki Shono

• Book ID: 104146666
• Publisher: Elsevier Science
• Year: 1984
• Tongue: English
• Weight: 177 KB
• Volume: 314
• Category: Article
• ISSN: 1873-3778
• DOI: 10.1016/s0021-9673(01)97733-7

✦ Synopsis

Both aand fl-cyclodextrin were converted into the ethylenediamine monosubstituted per-O-methyl derivatives, and the latter were coupled to succinamidopropyl silica. The resulting methylated a-cyclodextrin stationary phase improves the separation of the ortho, meta and para isomers of several disubstituted benzene derivatives, compared with the unmodified a-cyclodextrin stationary phase. Methylation of j?-cyclodextrin, however, results in less good selectivity in the separation of the three isomers. The methylated /?-cyclodextrin stationary phase can efficiently separate the antiepileptic drugs or the substituted naphthalene derivatives.