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Preparation and reactions of 1-(tert-butyldimethylsilyl)-3-lithioindole. Regioselective synthesis of 3-substituted indoles

✍ Scribed by Amat, Mercedes; Hadida, Sabine; Sathyanarayana, Swargam; Bosch, Joan


Book ID
120027055
Publisher
American Chemical Society
Year
1994
Tongue
English
Weight
249 KB
Volume
59
Category
Article
ISSN
0022-3263

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Palladium-catalyzed heteroarylation of 1
✍ Mercedes Amat; Sabine Hadida; Joan Bosch πŸ“‚ Article πŸ“… 1994 πŸ› Elsevier Science 🌐 French βš– 274 KB

Absfruck Palladium-catalyzed coupling of I-(rurr-hulyIdirnrthyl.\ilyl)-3-indolylzinc chloride (2) with either xdeficient or x-excedent heteroaryl halides gives krylindcdcs in good to excellenl yields. The method is extensively applied to !he preparation of J-(2-Fyridyl)indoles.