Regioselective Synthesis of Substituted Triazolium Saltsvia1,3-Dipolar Cycloaddition Reactions
โ Scribed by Atef M. Amer
- Publisher
- Springer Vienna
- Year
- 2003
- Tongue
- English
- Weight
- 392 KB
- Volume
- 134
- Category
- Article
- ISSN
- 0026-9247
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๐ SIMILAR VOLUMES
A facile synthesis of novel spiroindane-1,3-diones has been achieved via 1,3-dipolar cycloaddition of an azomethine ylide, generated in situ from ninhydrin and 1,2,3,4-tetrahydroisoquinoline, with the conjugated double bond of chalcone derivatives. The regiochemistry and structures of the cycloadduc
## Abstract Cycloaddition of an azomethine ylide, generated from ninhydrin and tetrahydroisoquinoline, with chalcones offers a novel diastereoselective synthesis of the target compounds.
N,N'-Diarylbisnitrile imides 2 add regioselectively to ยขt-(benzothiazol-2-yl)cinnamonitriles 3 and ct-(l-methylbenzimidazol-2-yl)cinnamonitriles 7 to yield exclusively the cycloadducts 5,5'-dicyano-4,4',5,5'-tetrahydro[3,3'-bi-lH-pyrazoles] 4 and 8, respectively. Compounds 4 and 8 undergo aromatizat